Hemophilia A is caused by a deficiency of clotting factor VIII. It is the most common Hemophilia, as about 85% of patients have type A. Acquired Hemophilia is an autoimmune disorder, (a disorder where the patient's body's own immune system mistakes its the healthy tissue as foreign), which attacks blood clotting factor VIII, thus, obstructing its purpose. Unfortunately, it is not widely recognized because it is so rare, as the majority of hemophilia cases are diagnosed early in childhood and are genetic. Unlike most hemophilia, which is most common in males, acquired hemophilia affects both men and women uniformly.
Also Read - Types Of Hemophilia
Obizur (susoctocog alfa), aims to prevent surgical bleeding in those with acquired hemophilia A. In a study, Successful perioperative prophylaxis with susoctocog alfa in a patient with acquired haemophilia A: A case study, sponsored by Takeda, researchers in Poland studied a 64-year-old man's experience with acquired hemophilia A and surgery, with the help of Obizur. He was given Obizur because the man reportedly had detectable levels of human version FVIII antibodies.
According to Hemophilia News Today, "The team noted a fair amount of variation in FVIII activity after surgery, and relatively high doses of Obizur were needed in the days immediately following the procedure. Researchers stressed the importance of actively monitoring FVIII activity in patients to ensure that the clotting factor’s activity is high enough to prevent bleeding."
You can read the study here: https://onlinelibrary.wiley.com/doi/10.1111/hae.14468
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