An article by Hayat El Maataoui, Amina Fahi, and Bouchra Oukkache of Casablanca, Maroc, analyzes the association of both HbAS (Sickle Cell) and major hemophilia A in two brothers.
Sickle cell disease is a genetic disorder of which the red blood cells in a patients blood are sticky and hard when exposed to low oxygen, causing blockages and constant shortages of red blood cells. It is estimated to affect 20-25 million people globally as there are several types of sickle cell disease. HbAs is a sickle cell trait, where the patient has one normal gene from the parent and one abnormal gene. This is similar to being a carrier of hemophilia.
It is extremely rare to have both hemophilia and a sickle cell trait (HbAs), which is why the Casablanca laboratory reported the case. The perplexing association of the two disorders was discovered after post-circumcision bleeding through a blood test. "We conclude that it is about a post-circumcision bleeding due to major hemophilia A associated to sickle cell AS, this association was a systematic discovery." The author(s) described the study as one that "deserved to be mentioned," as to bring attention to this rare circumstance. You can read the full report here: Read More
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