Hemophilia's history has been notable in European royalty as Queen Victoria (who was Queen of the United Kingdom of Great Britain and Ireland from 1837 to 1901), was a carrier of Hemophilia B, where she passed it on to one of her sons and two of her daughters. Her son, Leopold and her two daughters, Alice and Beatrice were passed Hemophilia which eventually was passed to Russian and Spanish royalty.
Alexei Nikolaevich of the House of Romanov in Russia was passed Hemophilia by his mother, Empress Alexandra. Alexei's Hemophilia would eventually lead to the rise of faith healer Grigori Rasputin, who tried to treat Alexei with aspirin (actually worsening the problem).
In Spain, Queen Victoria's daughter Beatrice, who was now Princess Beatrice, birthed a daughter named Victoria Eugenie. Victoria Eugenie eventually became the Queen of Spain and two of her sons were hemophiliacs, Alfonso and Infante Gonzalo.
Hemophiliacs suffered in the 19th and 20th centuries because there was no efficient treatment for it and the life expectancy was 13 years old. In 1964, a way to produce an antihemophilic factor was identified by Judith Graham Pool of Stanford University. This antihemophilic factor was approved for commercial use in 1971 in the United States and was called Cryoprecipitated AHF. Read more here.
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